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李小达 博士后

工学博士,现为中国科学院生物物理研究所与北京大学分子影像与转化医学联合实验室博士后

E-mail:lixiaoda339@126.com

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教育和研究背景:

09/1999-07/2004 中国科学技术大学,生命科学学院,神经退行性疾病实验室,生物物理与分子神经生物学专业,获得理学学士学位 (五年制本科),导师:周江宁 教授

主要研究方向:基因多态性与疾病相关性探讨

09/2004-07/2007 中国科学院近代物理研究所,中国科学院重离子束辐射生物医学重点实验室,生物物理学专业,获得生物物理学硕士学位 (三年制硕士),导师:张红 研究员

主要研究方向:辐射增敏剂的研发  

08/2007-03/2010 中国科学院高能物理研究所,中国科学院纳米生物效应与安全性重点实验室,实验室主任:赵宇亮 研究员

主要研究方向:纳米材料的生物安全性研究

03/2010-05/2015 哈尔滨工业大学,生命科学与技术学院,生物医学工程专业,获得工学博士学位(五年博士),导师:戴志飞 教授 (北京大学工学院)

主要研究方向:多功能造影剂的设计及研发

12/2015-至今中国科学院生物物理研究所与北京大学分子影像与转化医学联合实验室博士后,合作导师:王凡 教授

主要研究方向:多功能诊疗制剂设计及研发


发表论文:

1. Li X D, Liang X L, Ma F, et al. Chitosan stabilized prussian blue nanoparticles for photothermally enhanced gene delivery[J]. Colloids and Surfaces B: Biointerfaces, 2014, 123:629-638.

2. Li X D, Liang X L, Yue X L, et al. Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide[J]. J. Mater. Chem. B., 2014, 2: 217-223.

3. Li X D, Yue X L,  Wang J R, et al. Prussian Blue Nanoparticles Loaded Microbubbles for Photothermally Enhanced Gene Delivery through Ultrasound Targeted Microbubble Destruction[J]. Science Bulletin (Accept) 

4. Liang X L, Li X D, Yue X L, et al.  Conjugation of porphyrin to nanohybrid cerasomes for photodynamic diagnosis and therapy of cancer[J]. Angew Chem Int Ed., 2011, 50(49):11622-11627.  

5. Liang X L, Li X D, Jing L J, et al. Theranostic porphyrin dyad nanoparticles for magnetic resonance imaging guided photodynamic therapy[J]. Biomaterials, 2014, 35(24):6379-6388. 

6. Liang X L, Li X D, Jing L J, et al. Design and Synthesis of Lipidic Organoalkoxysilanes for the Self-Assembly of Liposomal Nanohybrid Cerasomes with Controlled Drug Release Properties[J]. Chem. Eur. J, 2013, 19(47): 16113-16121.  

7. Liang X L, Li Y Y, Li X D, et al. PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer[J]. Adv. Funct. Mater., 2015, 25(9):1451-1462. 

8. Jing L J, Liang X L, Li X D, et al. Mn-porphyrin conjugated Au nanoshells encapsulating doxorubicin for potential magnetic resonance imaging and light triggered synergistic therapy of cancer[J]. Theranostics, 2014, 4(9): 858-871. 

9. Jing L J, Liang X L, Li X D, et al. Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery[J]. Acta Biomater., 2013, 9(12): 9434-9441. 

10. Cao Z, Yue X L, Li X D, et al. Stabilized Magnetic Cerasomes for Drug Delivery[J], Langmuir, 2013, 29: 14976-14983. 

11. Yang Y B, Wang J R, Li X D, et al. A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction[J]. RSC Adv., 2015, 5: 8404-8414. 

12. Liang X L, Gao J, Jiang L D, Luo J W, Jing L J, Li X D, et al. Nanohybrid Liposomal Cerasomes with Good Physiological Stability and Rapid Temperature Responsiveness for High Intensity Focused Ultrasound Triggered Local Chemotherapy of Cancer[J]. ACS Nano., 2015, 9(2):1280-1293. 

13. Jing L J, Liang X L, Deng Z J, Feng S S, Li X D, et al. Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer [J]. Biomaterials. 2014, 35(22):5814-5821. 

14. Liang X L, Deng Z J, Jing L J, Li X D, et al. Prussian blue nanoparticles operate as a contrast agent for enhanced photoacoustic imaging [J]. Chem Commun (Camb). 2013, 49(94):11029-11031. 

15. Meng H, Xing G M, Blanco E, Song Y, Zhao L N, Sun B Y, Li X D, et al. Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells[J]. Nanomedicine. 2012, 8(2):136-146. 

16. Feng S S, Wang J R, Ma F, Liang X L, Li X D, et al. Prussian Blue modified PLA microcapsules containing R6G for ultrasonic/fluorescent bimodal imaging guided photothermal tumor therapy[J]. J Nanosci Nanotechnol ( Accept) 

17. Lin L, Li X D, Yang Y B, et al. Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect[J]. (Accept)

18. Zhang H, Zhou Q M, Li X D, et al. Ginsenoside R(e) increases fertile and asthenozoospermic infertile human sperm motility by induction of nitric oxide synthase[J], Arch Pharm Res, 2006, 29(2): 145-151. 

19. Zhang H, Zhou Q M, Li X D, et al. Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway[J], Mol Reprod Dev, 2007, 74(4): 497-501.

20. Zhang H, Zhang X, Yuan Z G, Li X D, et al. Germ cell loss induced by 12C6+ ion irradiation in young female mice [J] ,  J Radiat Res., 2006, 47(2): 131-134. 

21. Duan X, Zhang H, Liu B, Li X D, et al. Apoptosis of murine melanoma cells induced by heavy-ion radiation combined with Tp53 gene transfer[J], Int J Radiat Biol, 2008, 84(3): 211-217. 

22. Zhang H, Xie Y, Zhou Q M, Liu B, Li W J, Li X D. Adaptive hormetic response of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co c-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation[J], Adv Space Res, 2006, 38: 1148-1151. 

23. Zhang H, Duan X, Yuan Z G, Li W J, Zhou G M, Zhou Q M, Liu  B, Min F L, Li X D, et al. Chromosomal aberrations induced by 12C6+ ions and 60Co gamma-rays in mouse immature oocytes[J], Mutat Res, 2006, 595: 37-41. 

24. Zhang H, Liu B, Zhou Q M, Zhou G M, Yuan Z G, Li W J, Duan X, Min F L, Xie Y, Li X D. Alleviation of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co gamma-ray on male reproductive endocrine damages induced by subsequent high-dose irradiation[J], Int J Androl, 2006, 29(6): 592-6. 

25. 李小达,张红,高清祥,等,一氧化氮增强肝癌细胞(SMMC-7721)的辐射敏感性[J],中国组织工程研究与临床康复, 2007, 2: 1477-1480. 

26. 李小达,张红,高清祥,一氧化氮的放射增敏作用研究进展[J],中华放射医学与防护杂志, 2006, 6: 631 -632. 

27. 王燕玲,张红,段昕,刘兵,周清明,李小达,等,碳离子辐射对人肝癌细SMMC-7721细胞周期和P53、MDM2及P21表达的影响[J],辐射研究与辐射工艺学报, 2006, 24: 313-316.

28. 段昕,张红,邱嵘,高清祥,闵凤玲,郝冀芳,刘兵,周清明,李小达,等,重离子辐射提高腺病毒介导小鼠黑色素瘤细胞转染率的研究[J],原子核物理评论, 2007, 24: 55-57.


申请的专利

1. 戴志飞, 李小达, 梁晓龙, 傅光磊, 井立佳,林丽, 杨勇博,冯珊珊. 普鲁士蓝壳聚糖复合纳米粒子作为基因载体的新应用:中国,201310711145.2013-12-20.

2. 戴志飞, 梁晓龙, 李长辉, 邓梓建,井立佳, 黄毛毛,李小达. 普鲁士蓝纳米粒子作为光声成像造影剂的新用途:中国, 201310119420. 2013-04-08.

3. 戴志飞, 井立佳, 梁晓龙, 林丽, 李小达.一种长循环硅质体及其制备方法:中国, 201410054892. 2014-02-18.

4. 戴志飞,梁晓龙,蒋灵冬,井立佳,靳玉慎,李小达.温敏复合脂质体用于水溶性及两亲性抗癌药物的控制释放:中国, 201310711063. 2013-12-20.


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